Ontology highlight
ABSTRACT:
SUBMITTER: Dietsche T
PROVIDER: S-EPMC5158082 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Dietsche Tobias T Tesfazgi Mebrhatu Mehari M Brunner Matthias J MJ Abrusci Patrizia P Yan Jun J Franz-Wachtel Mirita M Schärfe Charlotta C Zilkenat Susann S Grin Iwan I Galán Jorge E JE Kohlbacher Oliver O Lea Susan S Macek Boris B Marlovits Thomas C TC Robinson Carol V CV Wagner Samuel S
PLoS pathogens 20161215 12
Bacterial type III protein secretion systems inject effector proteins into eukaryotic host cells in order to promote survival and colonization of Gram-negative pathogens and symbionts. Secretion across the bacterial cell envelope and injection into host cells is facilitated by a so-called injectisome. Its small hydrophobic export apparatus components SpaP and SpaR were shown to nucleate assembly of the needle complex and to form the central "cup" substructure of a Salmonella Typhimurium secretio ...[more]