Ontology highlight
ABSTRACT:
SUBMITTER: Kuhlen L
PROVIDER: S-EPMC6233869 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20180702 7
Export of proteins through type III secretion systems is critical for motility and virulence of many major bacterial pathogens. Three putative integral membrane proteins (FliP, FliQ, FliR) are suggested to form the core of an export gate in the inner membrane, but their structure, assembly and location within the final nanomachine remain unclear. Here, we present the cryoelectron microscopy structure of the Salmonella Typhimurium FliP-FliQ-FliR complex at 4.2 Å. None of the subunits adopt canoni ...[more]