A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens.
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ABSTRACT:
SUBMITTER: Rangan KJ
PROVIDER: S-EPMC5158264 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens.
Rangan Kavita J KJ Pedicord Virginia A VA Wang Yen-Chih YC Kim Byungchul B Lu Yun Y Shaham Shai S Mucida Daniel D Hang Howard C HC
Science (New York, N.Y.) 20160922 6306
The intestinal microbiome modulates host susceptibility to enteric pathogens, but the specific protective factors and mechanisms of individual bacterial species are not fully characterized. We show that secreted antigen A (SagA) from Enterococcus faecium is sufficient to protect Caenorhabditis elegans against Salmonella pathogenesis by promoting pathogen tolerance. The NlpC/p60 peptidoglycan hydrolase activity of SagA is required and generates muramyl-peptide fragments that are sufficient to pro ...[more]
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