Ontology highlight
ABSTRACT:
SUBMITTER: Rodgers ML
PROVIDER: S-EPMC5159527 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Rodgers Margaret L ML Didychuk Allison L AL Butcher Samuel E SE Brow David A DA Hoskins Aaron A AA
Nucleic acids research 20160802 22
The small nuclear RNA (snRNA) components of the spliceosome undergo many conformational rearrangements during its assembly, catalytic activation and disassembly. The U4 and U6 snRNAs are incorporated into the spliceosome as a base-paired complex within the U4/U6.U5 small nuclear ribonucleoprotein (tri-snRNP). U4 and U6 are then unwound in order for U6 to pair with U2 to form the spliceosome's active site. After splicing, U2/U6 is unwound and U6 annealed to U4 to reassemble the tri-snRNP. U6 rear ...[more]