Gene expression in local stroma reflects breast tumor states and predicts patient outcome.
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ABSTRACT:
SUBMITTER: Bainer R
PROVIDER: S-EPMC5159815 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Gene expression in local stroma reflects breast tumor states and predicts patient outcome.
Bainer Russell R Frankenberger Casey C Rabe Daniel D An Gary G Gilad Yoav Y Rosner Marsha Rich MR
Scientific reports 20161216
The surrounding microenvironment has been implicated in the progression of breast tumors to metastasis. However, the degree to which metastatic breast tumors locally reprogram stromal cells as they disrupt tissue boundaries is not well understood. We used species-specific RNA sequencing in a mouse xenograft model to determine how the metastasis suppressor RKIP influences transcription in a panel of paired tumor and stroma tissues. We find that gene expression in metastatic breast tumors is perva ...[more]
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