Elevated MED28 expression predicts poor outcome in women with breast cancer.
Ontology highlight
ABSTRACT: Background
MED28 (also known as EG-1 and magicin) has been implicated in transcriptional control, signal regulation, and cell proliferation. MED28 has also been associated with tumor progression in in vitro and in vivo models. Here we examined the association of MED28 expression with human breast cancer progression.Methods
Expression of MED28 protein was determined on a population basis using a high-density tissue microarray consisting of 210 breast cancer patients. The association and validation of MED28 expression with histopathological subtypes, clinicopathological variables, and disease outcome was assessed.Results
MED28 protein expression levels were increased in ductal carcinoma in situ and invasive ductal carcinoma of the breast compared to non-malignant glandular and ductal epithelium. Moreover, MED28 was a predictor of disease outcome in both univariate and multivariate analyses with higher expression predicting a greater risk of disease-related death.Conclusions
We have demonstrated that MED28 expression is increased in breast cancer. In addition, although the patient size was limited (88 individuals with survival information) MED28 is a novel and strong independent prognostic indicator of survival for breast cancer.
SUBMITTER: Yoon NK
PROVIDER: S-EPMC2907343 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Publications
Elevated MED28 expression predicts poor outcome in women with breast cancer.
Yoon Nam K NK Maresh Erin L EL Elshimali Yahya Y Li Ai A Horvath Steve S Seligson David B DB Chia David D Goodglick Lee L
BMC cancer 20100628
<h4>Background</h4>MED28 (also known as EG-1 and magicin) has been implicated in transcriptional control, signal regulation, and cell proliferation. MED28 has also been associated with tumor progression in in vitro and in vivo models. Here we examined the association of MED28 expression with human breast cancer progression.<h4>Methods</h4>Expression of MED28 protein was determined on a population basis using a high-density tissue microarray consisting of 210 breast cancer patients. The associati ...[more]
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