Ontology highlight
ABSTRACT:
SUBMITTER: Levchenko M
PROVIDER: S-EPMC5161373 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
PloS one 20161216 12
The outer mitochondrial membrane protein Atg32 is the central receptor for mitophagy, the mitochondria-specific form of autophagy. Atg32 is an unstable protein, and is rapidly degraded under conditions in which mitophagy is not induced. Here we show that Atg32 undergoes a posttranslational modification upon induction of mitophagy. The modification is dependent on the core autophagic machinery, including Atg8, and on the mitophagy-specific adaptor protein Atg11. The modified Atg32 is targeted to ...[more]