Ontology highlight
ABSTRACT:
SUBMITTER: Kafri P
PROVIDER: S-EPMC5161448 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Kafri Pinhas P Hasenson Sarah E SE Kanter Itamar I Sheinberger Jonathan J Kinor Noa N Yunger Sharon S Shav-Tal Yaron Y
eLife 20161123
Signal propagation from the cell membrane to a promoter can induce gene expression. To examine signal transmission through sub-cellular compartments and its effect on transcription levels in individual cells within a population, we used the Wnt/β-catenin signaling pathway as a model system. Wnt signaling orchestrates a response through nuclear accumulation of β-catenin in the cell population. However, quantitative live-cell measurements in individual cells showed variability in nuclear β-catenin ...[more]