Ontology highlight
ABSTRACT:
SUBMITTER: Heink S
PROVIDER: S-EPMC5164931 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Heink Sylvia S Yogev Nir N Garbers Christoph C Herwerth Marina M Aly Lilian L Gasperi Christiane C Husterer Veronika V Croxford Andrew L AL Möller-Hackbarth Katja K Bartsch Harald S HS Sotlar Karl K Krebs Stefan S Regen Tommy T Blum Helmut H Hemmer Bernhard B Misgeld Thomas T Wunderlich Thomas F TF Hidalgo Juan J Oukka Mohamed M Rose-John Stefan S Schmidt-Supprian Marc M Waisman Ari A Korn Thomas T
Nature immunology 20161128 1
The cellular sources of interleukin 6 (IL-6) that are relevant for differentiation of the T<sub>H</sub>17 subset of helper T cells remain unclear. Here we used a novel strategy for the conditional deletion of distinct IL-6-producing cell types to show that dendritic cells (DCs) positive for the signaling regulator Sirpα were essential for the generation of pathogenic T<sub>H</sub>17 cells. Using their IL-6 receptor α-chain (IL-6Rα), Sirpα<sup>+</sup> DCs trans-presented IL-6 to T cells during th ...[more]