Finding fusion genes resulting from chromosome rearrangement by analyzing the expressed sequence databases.
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ABSTRACT:
SUBMITTER: Hahn Y
PROVIDER: S-EPMC516526 | biostudies-literature | 2004 Sep
REPOSITORIES: biostudies-literature
Publications
Finding fusion genes resulting from chromosome rearrangement by analyzing the expressed sequence databases.
Hahn Yoonsoo Y Bera Tapan Kumar TK Gehlhaus Kristen K Kirsch Ilan R IR Pastan Ira H IH Lee Byungkook B
Proceedings of the National Academy of Sciences of the United States of America 20040823 36
Chromosomal rearrangements resulting in gene fusions are frequently involved in carcinogenesis. Here, we describe a semiautomatic procedure for identifying fusion gene transcripts by using publicly available mRNA and EST databases. With this procedure, we have identified 96 transcript sequences that are derived from 60 known fusion genes. Also, 47 or more additional sequences appear to be derived from 20 or more previously unknown putative fusion genes. We have experimentally verified the presen ...[more]
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