Ontology highlight
ABSTRACT:
SUBMITTER: Zavala-Ruiz Z
PROVIDER: S-EPMC516560 | biostudies-literature | 2004 Sep
REPOSITORIES: biostudies-literature
Zavala-Ruiz Zarixia Z Strug Iwona I Walker Bruce D BD Norris Philip J PJ Stern Lawrence J LJ
Proceedings of the National Academy of Sciences of the United States of America 20040826 36
T cells generally recognize peptide antigens bound to MHC proteins through contacts with residues found within or immediately flanking the seven- to nine-residue sequence accommodated in the MHC peptide-binding groove. However, some T cells require peptide residues outside this region for activation, the structural basis for which is unknown. Here, we have investigated a HIV Gag-specific T cell clone that requires an unusually long peptide antigen for activation. The crystal structure of a minim ...[more]