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Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling.


ABSTRACT: Interfollicular epidermal (IFE) homeostasis is a major physiological process allowing maintenance of the skin barrier function. Despite progress in our understanding of stem cell populations in different hair follicle compartments, cellular mechanisms of IFE maintenance, in particular, whether a hierarchy of progenitors exists within this compartment, have remained controversial. We here used multicolour lineage tracing with Brainbow transgenic labels activated in the epidermis to track individual keratinocyte clones. Two modes of clonal progression could be observed in the adult murine dorsal skin. Clones attached to hair follicles showed rapid increase in size during the growth phase of the hair cycle. On the other hand, clones distant from hair follicles were slow cycling, but could be mobilized by a proliferative stimulus. Reinforced by mathematical modelling, these data support a model where progenitor cycling characteristics are differentially regulated in areas surrounding or away from growing hair follicles. Thus, while IFE progenitors follow a non-hierarchical mode of development, spatiotemporal control by their environment can change their potentialities, with far-reaching implications for epidermal homeostasis, wound repair and cancer development.

SUBMITTER: Roy E 

PROVIDER: S-EPMC5167353 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling.

Roy Edwige E   Neufeld Zoltan Z   Cerone Luca L   Wong Ho Yi HY   Hodgson Samantha S   Livet Jean J   Khosrotehrani Kiarash K  

The EMBO journal 20161021 24


Interfollicular epidermal (IFE) homeostasis is a major physiological process allowing maintenance of the skin barrier function. Despite progress in our understanding of stem cell populations in different hair follicle compartments, cellular mechanisms of IFE maintenance, in particular, whether a hierarchy of progenitors exists within this compartment, have remained controversial. We here used multicolour lineage tracing with Brainbow transgenic labels activated in the epidermis to track individu  ...[more]

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