PptAB Exports Rgg Quorum-Sensing Peptides in Streptococcus.
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ABSTRACT:
SUBMITTER: Chang JC
PROVIDER: S-EPMC5167397 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
PptAB Exports Rgg Quorum-Sensing Peptides in Streptococcus.
Chang Jennifer C JC Federle Michael J MJ
PloS one 20161219 12
A transposon mutagenesis screen designed to identify mutants that were defective in peptide-pheromone signaling of the Rgg2/Rgg3 pathway in Streptococcus pyogenes generated insertions in sixteen loci displaying diminished reporter activity. Fourteen unique transposon insertions were mapped to pptAB, an ABC-type transporter recently described to export sex pheromones of Enterococcus faecalis. Consistent with an idea that PptAB exports signaling peptides, the pheromones known as SHPs (short hydrop ...[more]
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