Ontology highlight
ABSTRACT:
SUBMITTER: Tahara T
PROVIDER: S-EPMC5173132 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Tahara Tomomitsu T Shibata Tomoyuki T Okamoto Yasuyuki Y Yamazaki Jumpei J Kawamura Tomohiko T Horiguchi Noriyuki N Okubo Masaaki M Nakano Naoko N Ishizuka Takamitsu T Nagasaka Mitsuo M Nakagawa Yoshihito Y Ohmiya Naoki N
Oncotarget 20160701 27
<h4>Background and aim</h4>TP53 gene is frequently mutated in gastric cancer (GC), but the relationship with clinicopathological features and prognosis is conflicting. Here, we screened TP53 mutation spectrum of 214 GC patients in relation to their clinicopathological features and prognosis.<h4>Results</h4>TP53 nonsilent mutations were detected in 80 cases (37.4%), being frequently occurred as C:G to T:A single nucleotide transitions at 5'-CpG-3' sites. TP53 mutations occurred more frequently in ...[more]