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Timing of Physical Activity, Apolipoprotein E ?4 Genotype, and Risk of Incident Mild Cognitive Impairment.

ABSTRACT: OBJECTIVESTo investigate the timing (mid- vs late life) of physical activity, apolipoprotein (APO)E ?4, and risk of incident mild cognitive impairment (MCI).DESIGNProspective cohort study.SETTINGMayo Clinic Study of Aging (Olmsted County, MN).PARTICIPANTSCognitively normal elderly adults (N = 1,830, median age 78, 50.2% female).MEASUREMENTSLight, moderate, and vigorous physical activities in mid- and late life were assessed using a validated questionnaire. An expert consensus panel measured MCI based on published criteria. Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) with age as a time scale after adjusting for sex, education, medical comorbidity, and depression.RESULTSLight (HR = 0.58, 95% CI = 0.43-0.79) and vigorous (HR = 0.78, 95% CI = 0.63-0.97) physical activity in midlife were associated with lower risk of incident MCI. The association between moderate activity and incident MCI was not significant (HR = 0.85, 95% CI = 0.67-1.09). In late life, light (HR = 0.75, 95% CI = 0.58-0.97) and moderate (HR = 0.81, 95% CI = 0.66-0.99) but not vigorous physical activity were associated with lower risk of incident MCI. A synergistic interaction was also observed between mid- and late-life activity in reducing risk of incident MCI. Furthermore, APOE ?4 carriers who did not exercise had a higher risk of incident MCI than noncarriers who reported physical activity.CONCLUSIONPhysical activity reduced the risk of incident MCI. Exercising in mid- and late life had an additive synergistic interaction in reducing the risk of MCI.

SUBMITTER: Krell-Roesch J

PROVIDER: S-EPMC5173416 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Timing of Physical Activity, Apolipoprotein E ε4 Genotype, and Risk of Incident Mild Cognitive Impairment.

Krell-Roesch Janina J Pink Anna A Roberts Rosebud O RO Stokin Gorazd B GB Mielke Michelle M MM Spangehl Kathleen A KA Bartley Mairead M MM Knopman David S DS Christianson Teresa J H TJ Petersen Ronald C RC Geda Yonas E YE

Journal of the American Geriatrics Society 20161101 12

<h4>Objectives</h4>To investigate the timing (mid- vs late life) of physical activity, apolipoprotein (APO)E ε4, and risk of incident mild cognitive impairment (MCI).<h4>Design</h4>Prospective cohort study.<h4>Setting</h4>Mayo Clinic Study of Aging (Olmsted County, MN).<h4>Participants</h4>Cognitively normal elderly adults (N = 1,830, median age 78, 50.2% female).<h4>Measurements</h4>Light, moderate, and vigorous physical activities in mid- and late life were assessed using a validated questionn ...[more]

PMID: 27801933

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Project description:BACKGROUND:Apolipoprotein E (APOE) ?4 allele is a major genetic risk factor for Alzheimer disease and mild cognitive impairment (MCI). Computer-based training programs can improve cognitive performance in elderly populations. However, the effects of computer-based interventions on MCI APOE ?4 carriers have never been studied before. OBJECTIVE:The effects of different web-based interventions and the APOE isoform-specific differences in training outcomes are investigated. METHODS:Using a quasi-experimental study design, 202 participants with MCI aged 60 years and older took part in three different intervention programs (physical and cognitive [Long-Lasting Memories, or LLM], cognitive [Active Control, or AC], or physical intervention [Physical Training Control, or PTC]) via an innovative information and communication technologies exergaming platform. Participants in each interventional group were subdivided into APOE ?4 carriers and non-APOE ?4 carriers. All participants underwent an extensive neuropsychological evaluation before and after the training, blood tests, and brain imaging. RESULTS:All interventions resulted in multiple statistically significant cognitive benefits after the intervention. Verbal learning (California Verbal Learning Test: immediate recall test score-LLM: P=.04; AC: P<.001), working memory (digit span forward and backward test scores-AC: P=.03; PTC: P=.02 and P=.006, respectively), and long-term memory (California Verbal Learning Test: delayed recall test score-LLM: P=.02; AC: P=.002; and PTC: P=.02) were improved. There was no statistically significant difference among the intervention effects. APOE ?4 presence moderates intervention effects as the LLM intervention improved only their task-switching processing speed (Trail Making Test, Part B: P=.03) and the PTC intervention improved only the working memory (digit span backward: P=.03). No significant performance alteration was noted for the APOE ?4+ cognitive AC training group. CONCLUSIONS:None of the applied interventions could be identified as the optimal one; it is suggested, however, that combined cognitive and physical training and physical training via exergaming may be more effective for the high-risk MCI ?POE ?4+ subgroup.

Dataset Information

Timing of Physical Activity, Apolipoprotein E ?4 Genotype, and Risk of Incident Mild Cognitive Impairment.

Publications

Timing of Physical Activity, Apolipoprotein E ε4 Genotype, and Risk of Incident Mild Cognitive Impairment.

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