Dataset Information

Physical activity modifies the influence of apolipoprotein E ?4 allele and type 2 diabetes on dementia and cognitive impairment among older Mexican Americans.

ABSTRACT: INTRODUCTION:The etiologies of dementia are complex and influenced by genetic and environmental factors including medical conditions. METHODS:We used Cox regression model to estimate the individual and joint effects of physical activity (PA), apolipoprotein E (APOE) ?4, and diabetes status on risk of dementia and cognitive impairment without dementia (CIND) among 1438 cognitively intact Mexican American elderly who were followed up to 10 years. RESULTS:The risk of developing dementia/CIND was increased more than threefold in APOE ?4 carriers or diabetics with low levels of PA compared with ?4 noncarriers or nondiabetics who engaged in high PA (?4: hazard ratio [HR] = 3.44, 95% confidence interval [CI] = 1.85-6.39; diabetes: HR = 3.11, 95% CI = 1.87-5.18); the presence of all three risk factors increased risk by nearly 10-fold (HR = 9.49, 95% CI = 3.57-25.3). DISCUSSION:PA in elderly Hispanics protects strongly against the onset of dementia/CIND, especially in APOE ?4 carriers and those who have diabetes.

SUBMITTER: Shih IF

PROVIDER: S-EPMC5750101 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Physical activity modifies the influence of apolipoprotein E ε4 allele and type 2 diabetes on dementia and cognitive impairment among older Mexican Americans.

Shih I-Fan IF Paul Kimberly K Haan Mary M Yu Yu Y Ritz Beate B

Alzheimer's & dementia : the journal of the Alzheimer's Association 20170708 1

<h4>Introduction</h4>The etiologies of dementia are complex and influenced by genetic and environmental factors including medical conditions.<h4>Methods</h4>We used Cox regression model to estimate the individual and joint effects of physical activity (PA), apolipoprotein E (APOE) ε4, and diabetes status on risk of dementia and cognitive impairment without dementia (CIND) among 1438 cognitively intact Mexican American elderly who were followed up to 10 years.<h4>Results</h4>The risk of developin ...[more]

PMID: 28692819

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Project description:BackgroundThe association between stroke and dementia is well established. Less is known about this association in underrepresented ethnic groups. In a large ethnically diverse cohort, we examined whether history of stroke was associated with cognitive impairment, and whether this relationship differed by ethnicity (Mexican American [MA] versus non-Hispanic White).MethodsThis was a population-based cohort study conducted in Nueces County, TX, a biethnic community with a large and primarily nonimmigrant MA population. Residents aged ≥65 were recruited door-to-door or by telephone between May 2018 and December 2021. The primary exposure was history of stroke, obtained by self-report. Demographic, medical, and educational histories were also obtained. The primary outcome was the Montreal Cognitive Assessment (MoCA), a scale that evaluates multiple domains of cognitive performance. Scores were divided into 3 ordinal categories, roughly corresponding to normal cognition (MoCA 26-30), mild cognitive impairment (MoCA 20-25), or probable dementia (MoCA 0-19).ResultsOne thousand eight hundred one participants completed MoCA screening (55% female; 50% MA, 44% Non-Hispanic White, 6% other), of whom 12.4% reported history of stroke. Stroke prevalence was similar across ethnicities (X2 2.1; P=0.34). In a multivariable cumulative logit regression model for the ordinal cognition outcome, a stroke by ethnicity interaction was observed (P=0.01). Models stratified by ethnicity revealed that stroke was associated with cognitive impairment across ethnicities, but had greater impact on cognition in non-Hispanic Whites (cumulative odds ratio=3.81 [95% CI, 2.37-6.12]) than in MAs (cumulative odds ratio=1.58 [95% CI, 1.04-2.41]). Increased age and lower educational attainment were also associated with cognitive impairment, regardless of ethnicity.ConclusionsHistory of stroke was associated with increased odds of cognitive impairment after controlling for other factors in both MA and Non-Hispanic White participants. The magnitude of the impact of stroke on cognition was less in MA than in Non-Hispanic White participants.

Dataset Information

Physical activity modifies the influence of apolipoprotein E ?4 allele and type 2 diabetes on dementia and cognitive impairment among older Mexican Americans.

Publications

Physical activity modifies the influence of apolipoprotein E ε4 allele and type 2 diabetes on dementia and cognitive impairment among older Mexican Americans.

Similar Datasets

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