Dataset Information

Physical activity modifies the influence of apolipoprotein E ?4 allele and type 2 diabetes on dementia and cognitive impairment among older Mexican Americans.

ABSTRACT: INTRODUCTION:The etiologies of dementia are complex and influenced by genetic and environmental factors including medical conditions. METHODS:We used Cox regression model to estimate the individual and joint effects of physical activity (PA), apolipoprotein E (APOE) ?4, and diabetes status on risk of dementia and cognitive impairment without dementia (CIND) among 1438 cognitively intact Mexican American elderly who were followed up to 10 years. RESULTS:The risk of developing dementia/CIND was increased more than threefold in APOE ?4 carriers or diabetics with low levels of PA compared with ?4 noncarriers or nondiabetics who engaged in high PA (?4: hazard ratio [HR] = 3.44, 95% confidence interval [CI] = 1.85-6.39; diabetes: HR = 3.11, 95% CI = 1.87-5.18); the presence of all three risk factors increased risk by nearly 10-fold (HR = 9.49, 95% CI = 3.57-25.3). DISCUSSION:PA in elderly Hispanics protects strongly against the onset of dementia/CIND, especially in APOE ?4 carriers and those who have diabetes.

SUBMITTER: Shih IF

PROVIDER: S-EPMC5750101 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Physical activity modifies the influence of apolipoprotein E ε4 allele and type 2 diabetes on dementia and cognitive impairment among older Mexican Americans.

Shih I-Fan IF Paul Kimberly K Haan Mary M Yu Yu Y Ritz Beate B

Alzheimer's & dementia : the journal of the Alzheimer's Association 20170708 1

<h4>Introduction</h4>The etiologies of dementia are complex and influenced by genetic and environmental factors including medical conditions.<h4>Methods</h4>We used Cox regression model to estimate the individual and joint effects of physical activity (PA), apolipoprotein E (APOE) ε4, and diabetes status on risk of dementia and cognitive impairment without dementia (CIND) among 1438 cognitively intact Mexican American elderly who were followed up to 10 years.<h4>Results</h4>The risk of developin ...[more]

PMID: 28692819

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Project description:BackgroundType 2 diabetes is a leading contributor to the global burden of morbidity and mortality. Ozone (O3) exposure has previously been linked to diabetes.ObjectiveWe studied the impact of O3 exposure on incident diabetes risk in elderly Mexican Americans and investigated whether outdoor physical activity modifies the association.MethodsWe selected 1,090 Mexican American participants from the Sacramento Area Latino Study on Aging conducted from 1998 to 2007. Ambient O3 exposure levels were modeled with a land-use regression built with saturation monitoring data collected at 49 sites across the Sacramento metropolitan area. Using Cox proportional hazard models, we estimated the risk of developing incident diabetes based on average O3 exposure modeled for 5-y prior to incident diabetes diagnosis or last follow-up. Further, we estimated outdoor leisure-time physical activity at baseline and investigated whether higher vs. lower levels modified the association between O3 exposure and diabetes.ResultsIn total, 186 incident diabetes cases were identified during 10-y follow-up. Higher levels of physical activity were negatively associated with incident diabetes [hazard ratio (HR)=0.64 (95% CI: 0.43, 0.95)]. The estimated HRs for incident diabetes was 1.13 (95% CI: 1.00, 1.28) per 10-ppb increment of 5-y average O3 exposure; also, this association was stronger among those physically active outdoors [HR=1.52 (95% CI: 1.21, 1.90)], and close to null for those reporting lower levels of outdoor activity [HR=1.04 (95% CI: 0.90, 1.20), pinteraction=0.01].ConclusionsOur findings suggest that ambient O3 exposure contributes to the development of type 2 diabetes, particularly among those with higher levels of leisure-time outdoor physical activity. Policies and strategies are needed to reduce O3 exposure to guarantee that the health benefits of physical activity are not diminished by higher levels of O3 pollution in susceptible populations such as older Hispanics. https://doi.org/10.1289/EHP8620.

Dataset Information

Physical activity modifies the influence of apolipoprotein E ?4 allele and type 2 diabetes on dementia and cognitive impairment among older Mexican Americans.

Publications

Physical activity modifies the influence of apolipoprotein E ε4 allele and type 2 diabetes on dementia and cognitive impairment among older Mexican Americans.

Similar Datasets

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