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ABSTRACT:
SUBMITTER: Tasnima N
PROVIDER: S-EPMC5173422 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Tasnima Nova N Yu Hai H Li Yanhong Y Santra Abhishek A Chen Xi X
Organic & biomolecular chemistry 20161201 1
para-Nitrophenol (pNP)-tagged α2-8-linked sialosides containing different sialic acid forms were chemoenzymatically synthesized using an efficient one-pot three-enzyme α2-8-sialylation system. The resulting compounds allowed high-throughput substrate specificity studies of the α2-8-sialidase activity of a recombinant human cytosolic sialidase hNEU2 and various bacterial sialidases. The sialoside substrate profiles obtained can be used to guide the selection of suitable sialidases for sialylglyca ...[more]