Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC5175466 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20161024 47
Hydrogen sulfide (H<sub>2</sub> S) exhibits promising protective effects in many (patho)physiological processes, as evidenced by recent reports using synthetic H<sub>2</sub> S donors in different biological models. Herein, we report the design and evaluation of compounds denoted PeroxyTCM, which are the first class of reactive oxygen species (ROS)-triggered H<sub>2</sub> S donors. These donors are engineered to release carbonyl sulfide (COS) upon activation, which is quickly hydrolyzed to H<sub> ...[more]