Ontology highlight
ABSTRACT:
SUBMITTER: Ceribelli M
PROVIDER: S-EPMC5175469 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Ceribelli Michele M Hou Zhiying Esther ZE Kelly Priscilla N PN Huang Da Wei DW Wright George G Ganapathi Karthik K Evbuomwan Moses O MO Pittaluga Stefania S Shaffer Arthur L AL Marcucci Guido G Forman Stephen J SJ Xiao Wenming W Guha Rajarshi R Zhang Xiaohu X Ferrer Marc M Chaperot Laurence L Plumas Joel J Jaffe Elaine S ES Thomas Craig J CJ Reizis Boris B Staudt Louis M LM
Cancer cell 20161101 5
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive and largely incurable hematologic malignancy originating from plasmacytoid dendritic cells (pDCs). Using RNAi screening, we identified the E-box transcription factor TCF4 as a master regulator of the BPDCN oncogenic program. TCF4 served as a faithful diagnostic marker of BPDCN, and its downregulation caused the loss of the BPDCN-specific gene expression program and apoptosis. High-throughput drug screening revealed that bromod ...[more]