Dataset Information

Serum C-reactive protein in adolescence and risk of schizophrenia in adulthood: A prospective birth cohort study.

ABSTRACT:

Objective

Meta-analyses of cross-sectional studies confirm an increase in circulating inflammatory markers during acute psychosis. Longitudinal studies are scarce but are needed to understand whether elevated inflammatory markers are a cause or consequence of illness. We report a longitudinal study of serum C-reactive protein (CRP) in adolescence and subsequent risk of schizophrenia and related psychoses in adulthood in the Northern Finland Birth Cohort 1986.

Method

Serum high-sensitivity CRP was measured at age 15/16 years in 6362 participants. ICD-10 diagnoses of schizophrenia and related psychoses were obtained from centralised hospital inpatient and outpatient registers up to age 27 years. Logistic regression calculated odds ratios (ORs) for psychotic outcomes associated with baseline CRP levels analysed as both continuous and categorical variables using American Heart Association criteria. Age, sex, body mass index, maternal education, smoking, and alcohol use were included as potential confounders.

Results

By age 27years, 88 cases of non-affective psychosis (1.38%), of which 22 were schizophrenia (0.35%), were identified. Adolescent CRP was associated with subsequent schizophrenia. The adjusted OR for schizophrenia by age 27yearsfor each standard deviation (SD) increase in CRP levels at age 15/16yearswas 1.25 (95% CI, 1.07-1.46), which was consistent with a linear, dose-response relationship (P-value for quadratic term 0.23). Using CRP as a categorical variable, those with high (>3mg/L) compared with low (<1mg/L) CRP levels at baseline were more likely to develop schizophrenia; adjusted OR 4.25 (95% CI, 1.30-13.93). There was some indication that higher CRP was associated with earlier onset of schizophrenia (r_s=-0.40; P=0.07).

Conclusions

A longitudinal association between adolescent CRP levels and adult schizophrenia diagnosis indicates a potentially important role of inflammation in the pathogenesis of the illness, although the findings, based on a small number of cases, need to be interpreted with caution and require replication in other samples.

SUBMITTER: Metcalf SA

PROVIDER: S-EPMC5176002 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Publications

Serum C-reactive protein in adolescence and risk of schizophrenia in adulthood: A prospective birth cohort study.

Metcalf Stephen A SA Jones Peter B PB Nordstrom Tanja T Timonen Markku M Mäki Pirjo P Miettunen Jouko J Jääskeläinen Erika E Järvelin Marjo-Riitta MR Stochl Jan J Murray Graham K GK Veijola Juha J Khandaker Golam M GM

Brain, behavior, and immunity 20160910

<h4>Objective</h4>Meta-analyses of cross-sectional studies confirm an increase in circulating inflammatory markers during acute psychosis. Longitudinal studies are scarce but are needed to understand whether elevated inflammatory markers are a cause or consequence of illness. We report a longitudinal study of serum C-reactive protein (CRP) in adolescence and subsequent risk of schizophrenia and related psychoses in adulthood in the Northern Finland Birth Cohort 1986.<h4>Method</h4>Serum high-sen ...[more]

PMID: 27622678

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Dataset Information

Serum C-reactive protein in adolescence and risk of schizophrenia in adulthood: A prospective birth cohort study.

Objective

Method

Results

Conclusions

Publications

Serum C-reactive protein in adolescence and risk of schizophrenia in adulthood: A prospective birth cohort study.

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