Ontology highlight
ABSTRACT:
SUBMITTER: Chopera DR
PROVIDER: S-EPMC5177455 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Chopera Denis R DR Ntale Roman R Ndabambi Nonkululeko N Garrett Nigel N Gray Clive M CM Matten David D Abdool Karim Quarraisha Q Abdool Karim Salim S Williamson Carolyn C
AIDS (London, England) 20170101 2
<h4>Objective</h4>HIV-1 escape from cytotoxic T-lymphocytes results in the accumulation of human leucocyte antigen (HLA)-associated mutations in the viral genome. To understand the contribution of early escape to disease progression, this study investigated the evolution and pathogenic implications of cytotoxic T-lymphocyte escape in a cohort followed from infection for 5 years.<h4>Methods</h4>Viral loads and CD4 cell counts were monitored in 78 subtype C-infected individuals from onset of infec ...[more]