Dataset Information

Association of Functional Impairments and Co-Morbid Conditions with Driving Performance among Cognitively Normal Older Adults.

ABSTRACT:

Objectives

To examine the relationship between key functional impairments, co-morbid conditions and driving performance in a sample of cognitively normal older adults.

Design

Prospective observational study.

Setting

The Knight Alzheimer's Disease Research Center, Washington University at St. Louis.

Participants

Individuals with normal cognition, 64.9 to 88.2 years old (N = 129), with a valid driver's license, who were currently driving at least once per week, and who had participated in longitudinal studies at the Knight Alzheimer's Disease Research Center.

Measurements

Static visual acuity, contrast sensitivity, physical frailty measures, motor skills, total medical conditions, and the modified Washington University Road Test.

Results

When controlling for age, race, gender, APOE, and education the total number of medical conditions was unassociated with both road test scores (pass vs. marginal + fail) and the total driver error count. There were marginal associations of our measure of physical frailty (p = 0.06) and contrast sensitivity score (p = 0.06) with total driving error count.

Conclusion

Future research that focuses on older adults and driving should consider adopting measures of physical frailty and contrast sensitivity, especially in samples that may have a propensity for disease impacting visual and/or physical function (e.g. osteoarthritis, Parkinson's, eye disorders, advanced age >80 years, etc.).

SUBMITTER: Carr DB

PROVIDER: S-EPMC5179007 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association of Functional Impairments and Co-Morbid Conditions with Driving Performance among Cognitively Normal Older Adults.

Carr David B DB Barco Peggy P PP Babulal Ganesh M GM Stout Sarah H SH Johnson Anne M AM Xiong Chengjie C Morris John C JC Roe Catherine M CM

PloS one 20161222 12

<h4>Objectives</h4>To examine the relationship between key functional impairments, co-morbid conditions and driving performance in a sample of cognitively normal older adults.<h4>Design</h4>Prospective observational study.<h4>Setting</h4>The Knight Alzheimer's Disease Research Center, Washington University at St. Louis.<h4>Participants</h4>Individuals with normal cognition, 64.9 to 88.2 years old (N = 129), with a valid driver's license, who were currently driving at least once per week, and who ...[more]

PMID: 28005921

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Project description:IntroductionLate onset Alzheimer's disease (AD) is the most common form of dementia, in which almost 70% of patients are women.HypothesisWe hypothesized that women show worse global FC metrics compared to men, and further hypothesized a sex-specific positive correlation between FC metrics and cognitive scores in women.MethodsWe studied cognitively healthy individuals from the Alzheimer's Disease Neuroimaging Initiative cohort, with resting-state functional Magnetic Resonance Imaging. Metrics derived from graph theoretical analysis and functional connectomics were used to assess the global/regional sex differences in terms of functional integration and segregation, considering the amyloid status and the contributions of APOE E4. Linear mixed effect models with covariates (education, handedness, presence of apolipoprotein [APOE] E4 and intra-subject effect) were utilized to evaluate sex differences. The associations of verbal learning and memory abilities with topological network properties were assessed.ResultWomen had a significantly lower magnitude of the global and regional functional network metrics compared to men. Exploratory association analysis showed that higher global clustering coefficient was associated with lower percent forgetting in women and worse cognitive scores in men.ConclusionWomen overall show lower magnitude on measures of resting state functional network topology and connectivity. This factor can play a role in their different vulnerability to AD.Significance statementTwo thirds of AD patients are women but the reasons for these sex difference are not well understood. When this late onset form dementia arises is too late to understand the potential causes of this sex disparities. Studies on cognitively healthy elderly population are a fundamental approach to explore in depth this different vulnerability to the most common form of dementia, currently affecting 6.2 million Americans aged 65 and older are, which means that >1 in 9 people (11.3%) 65 and older are affected by AD. Approaches such as resting-state functional network topology and connectivity may play a key role in understanding and elucidate sex-dependent differences relevant to late-onset dementia syndromes.

Dataset Information

Association of Functional Impairments and Co-Morbid Conditions with Driving Performance among Cognitively Normal Older Adults.

Objectives

Design

Setting

Participants

Measurements

Results

Conclusion

Publications

Association of Functional Impairments and Co-Morbid Conditions with Driving Performance among Cognitively Normal Older Adults.

Similar Datasets

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