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Safety of disclosing amyloid status in cognitively normal older adults.


ABSTRACT: INTRODUCTION:Disclosing amyloid status to cognitively normal individuals remains controversial given our lack of understanding the test's clinical significance and unknown psychological risk. METHODS:We assessed the effect of amyloid status disclosure on anxiety and depression before disclosure, at disclosure, and 6 weeks and 6 months postdisclosure and test-related distress after disclosure. RESULTS:Clinicians disclosed amyloid status to 97 cognitively normal older adults (27 had elevated cerebral amyloid). There was no difference in depressive symptoms across groups over time. There was a significant group by time interaction in anxiety, although post hoc analyses revealed no group differences at any time point, suggesting a minimal nonsustained increase in anxiety symptoms immediately postdisclosure in the elevated group. Slight but measureable increases in test-related distress were present after disclosure and were related to greater baseline levels of anxiety and depression. DISCUSSION:Disclosing amyloid imaging results to cognitively normal adults in the clinical research setting with pre- and postdisclosure counseling has a low risk of psychological harm.

SUBMITTER: Burns JM 

PROVIDER: S-EPMC5582024 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Safety of disclosing amyloid status in cognitively normal older adults.

Burns Jeffrey M JM   Johnson David K DK   Liebmann Edward P EP   Bothwell Rebecca J RJ   Morris Jill K JK   Vidoni Eric D ED  

Alzheimer's & dementia : the journal of the Alzheimer's Association 20170303 9


<h4>Introduction</h4>Disclosing amyloid status to cognitively normal individuals remains controversial given our lack of understanding the test's clinical significance and unknown psychological risk.<h4>Methods</h4>We assessed the effect of amyloid status disclosure on anxiety and depression before disclosure, at disclosure, and 6 weeks and 6 months postdisclosure and test-related distress after disclosure.<h4>Results</h4>Clinicians disclosed amyloid status to 97 cognitively normal older adults  ...[more]

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