Common SNP rs6564851 in the BCO1 Gene Affects the Circulating Levels of ?-Carotene and the Daily Intake of Carotenoids in Healthy Japanese Women.

ABSTRACT: The circulating levels of ?-carotene are modulated not only by sex, but also by autosomal gene variations and fruit intake. The aim of this study was to investigate the interactions between ?-carotene metabolism-related gene single nucleotide polymorphisms (SNPs; genetic factors) and nutrient intake (environmental factors) relating to their effects on circulating ?-carotene. The serum concentrations of ?-carotene and the habitual food intake of 92 healthy Japanese adults were examined. All subjects were genotyped for three common SNPs: rs6564851 in the ?-carotene 15,15'-oxygenase 1 (BCO1) gene, rs2278986 in the scavenger receptor class B member 1 (SCARB1) gene and rs362090 in the intestine-specific homeobox (ISX) gene. Univariate analysis revealed that the circulating ?-carotene levels were significantly higher in rs6564851 GG homozygotes (p = 0.003). Additionally, the daily intake of ?-cryptoxanthin was positively associated with the circulating ?-carotene levels in female GG homozygotes of rs6564851 (p = 0.023), and the daily intake of ?- and ?-carotenes, and ?-cryptoxanthin was significantly lower in female rs6564851 T allele carries than in female GG homozygotes (p = 0.009, 0.008, 0.009, respectively). The present study apparently indicates that higher circulating ?-carotene levels in female rs6564851 GG homozygotes depend on carotenoid intake.

SUBMITTER: Yabuta S 

PROVIDER: S-EPMC5179075 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature