Ontology highlight
ABSTRACT:
SUBMITTER: Di Fiore B
PROVIDER: S-EPMC5179498 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Molecular cell 20161208 6
The Spindle Assembly Checkpoint (SAC) ensures genomic stability by preventing sister chromatid separation until all chromosomes are attached to the spindle. It catalyzes the production of the Mitotic Checkpoint Complex (MCC), which inhibits Cdc20 to inactivate the Anaphase Promoting Complex/Cyclosome (APC/C). Here we show that two Cdc20-binding motifs in BubR1 of the recently identified ABBA motif class are crucial for the MCC to recognize active APC/C-Cdc20. Mutating these motifs eliminates MCC ...[more]