Ontology highlight
ABSTRACT:
SUBMITTER: Hoffman H
PROVIDER: S-EPMC5180420 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Methods in enzymology 20160510
Telomeres are nucleoprotein complexes that maintain the ends of our chromosomes thus providing genomic stability. Telomerase is a ribonucleoprotein reverse transcriptase that replicates the short tandem repeats of DNA known as telomeres. The telomeric DNA is specifically associated with two major complexes, the shelterin and CST complexes both of which are involved in telomere length regulation and maintenance along with telomerase. Obtaining structural information on these nucleoprotein complex ...[more]