Ontology highlight
ABSTRACT:
SUBMITTER: Yue F
PROVIDER: S-EPMC5181649 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Yue Feng F Bi Pengpeng P Wang Chao C Li Jie J Liu Xiaoqi X Kuang Shihuan S
Cell reports 20161101 9
Skeletal muscle stem cells (satellite cells [SCs]) are normally maintained in a quiescent (G<sub>0</sub>) state. Muscle injury not only activates SCs locally, but also alerts SCs in distant uninjured muscles via circulating factors. The resulting G<sub>Alert</sub> SCs are adapted to regenerative cues and regenerate injured muscles more efficiently, but whether they provide any long-term benefits to SCs is unknown. Here, we report that embryonic myogenic progenitors lacking the phosphatase and te ...[more]