Unknown

Dataset Information

0

C-KIT Expression Distinguishes Fetal from Postnatal Skeletal Progenitors.


ABSTRACT: Hematopoietic stem cells (HSCs) and skeletal stem cells (SSCs) cohabit in the bone marrow. KITL (C-KIT ligand) from LEPR+ adult bone marrow stromal cells is pivotal for HSC maintenance. In contrast, it remains unclear whether KITL/C-KIT signaling also regulates SSCs. Here, we lineage traced C-KIT+ cells and found that C-KIT was expressed by fetal, but not postnatal skeletal progenitors. Fetal C-KIT+ cells gave rise to 20% of LEPR+ stromal cells in adult bone marrow, forming nearly half of all osteoblasts. Disruption of mTOR signaling in fetal C-KIT+ cells impaired bone formation. Notably, conditional deletion of Kitl from PRX1+ fetal bone marrow stromal cells, but not LEPR+ adult bone marrow stromal cells, significantly increased bone formation. Thus, our work identified C-KIT+ skeletal progenitors as an important source of bones formed during development.

SUBMITTER: He DD 

PROVIDER: S-EPMC7160391 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC3216340 | biostudies-literature
| S-EPMC3650009 | biostudies-literature
| S-EPMC3371733 | biostudies-literature
2012-02-17 | GSE35214 | GEO
| S-EPMC8358609 | biostudies-literature
2012-02-17 | E-GEOD-35214 | biostudies-arrayexpress
| S-EPMC3797556 | biostudies-literature
| S-EPMC5181649 | biostudies-literature
| S-EPMC3679295 | biostudies-other
| S-SCDT-10_1038-S44319-024-00093-X | biostudies-other