Ontology highlight
ABSTRACT:
SUBMITTER: Kang H
PROVIDER: S-EPMC5182193 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Clinical cancer research : an official journal of the American Association for Cancer Research 20160623 1
<h4>Purpose</h4>Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. To explore the genetic origins of MEC, we performed systematic genomic analyses of these tumors.<h4>Experimental design</h4>Whole-exome sequencing and gene copy-number analyses were performed for 18 primary cancers with matched normal tissue. FISH was used to determine the presence or absence of the MECT1-MAML2 translocation in 17 tumors.<h4>Results</h4>TP53 was the most commonly mutated gene in MEC (28% ...[more]