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Whole-exome and whole-transcriptome sequencing of canine mammary gland tumors.

ABSTRACT: Studies of naturally occurring cancers in dogs, which share many genetic and environmental factors with humans, provide valuable information as a comparative model for studying the mechanisms of human cancer pathogenesis. While individual and small-scale studies of canine cancers are underway, more generalized multi-omics studies have not been attempted due to the lack of large-scale and well-controlled genomic data. Here, we produced reliable whole-exome and whole-transcriptome sequencing data of 197 canine mammary cancers and their matched controls, annotated with rich clinical and biological features. Our dataset provides useful reference points for comparative analysis with human cancers and for developing novel diagnostic and therapeutic technologies for cancers in pet dogs.

SUBMITTER: Kim KK

PROVIDER: S-EPMC6694171 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Whole-exome and whole-transcriptome sequencing of canine mammary gland tumors.

Kim Ka-Kyung KK Seung Byung-Joon BJ Kim Dohyun D Park Hee-Myung HM Lee Sejoon S Song Doo-Won DW Lee Gunho G Cheong Jae-Ho JH Nam Hojung H Sur Jung-Hyang JH Kim Sangwoo S

Scientific data 20190814 1

Studies of naturally occurring cancers in dogs, which share many genetic and environmental factors with humans, provide valuable information as a comparative model for studying the mechanisms of human cancer pathogenesis. While individual and small-scale studies of canine cancers are underway, more generalized multi-omics studies have not been attempted due to the lack of large-scale and well-controlled genomic data. Here, we produced reliable whole-exome and whole-transcriptome sequencing data ...[more]

PMID: 31413331

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