Ontology highlight
ABSTRACT:
SUBMITTER: Alencar AK
PROVIDER: S-EPMC5183553 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Alencar Allan K AK Montes Guilherme C GC Montagnoli Tadeu T Silva Ananssa M AM Martinez Sabrina T ST Fraga Aline G AG Wang Hao H Groban Leanne L Sudo Roberto T RT Zapata-Sudo Gisele G
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20161109
<h4>Rationale</h4>Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling that leads to pulmonary congestion, uncompensated right-ventricle (RV) failure, and premature death. Preclinical studies have demonstrated that the G protein-coupled estrogen receptor (GPER) is cardioprotective in male rats and that its activation elicits vascular relaxation in rats of either sex.<h4>Objectives</h4>To study the effects of GPER on the cardiopulmonary system by the administration of its ...[more]