Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension.
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ABSTRACT:
SUBMITTER: Yoshida K
PROVIDER: S-EPMC6234524 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
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Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension.
Yoshida Keimei K Saku Keita K Kamada Kazuhiro K Abe Kohtaro K Tanaka-Ishikawa Mariko M Tohyama Takeshi T Nishikawa Takuya T Kishi Takuya T Sunagawa Kenji K Tsutsui Hiroyuki H
JACC. Basic to translational science 20181001 5
This study aimed to elucidate the therapeutic effects of electrical vagal nerve stimulation (VNS) on severe pulmonary arterial hypertension in a rat model. In a pathophysiological study, VNS significantly restored autonomic balance, decreased mean pulmonary arterial pressure, attenuated pulmonary vascular remodeling, and preserved right ventricular function. In a survival study, VNS significantly improved the survival rate in both the prevention (VNS from 0 to 5 weeks after a SU5416 injection) a ...[more]
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