Ontology highlight
ABSTRACT:
SUBMITTER: Lin VC
PROVIDER: S-EPMC5187796 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Lin Victor C VC Lu Te-Ling TL Yin Hsin-Ling HL Yang Sheau-Fang SF Lee Yung-Chin YC Liu Chia-Chu CC Huang Chao-Yuan CY Yu Chia-Cheng CC Chang Ta-Yuan TY Huang Shu-Pin SP Bao Bo-Ying BY
International journal of molecular sciences 20161129 12
Folate metabolism has been associated with cancers via alterations in nucleotide synthesis, DNA methylation, and DNA repair. We hypothesized that genetic variants in methylenetetrahydrofolate reductase (<i>MTHFR</i>), a key enzyme of folate metabolism, would affect the prognosis of prostate cancer. Three haplotype-tagging single-nucleotide polymorphisms (SNPs) across the <i>MTHFR</i> gene region were genotyped in a cohort of 458 patients with clinically localized prostate cancer treated with rad ...[more]