Ontology highlight
ABSTRACT:
SUBMITTER: Van Rhijn I
PROVIDER: S-EPMC518797 | biostudies-literature | 2004 Sep
REPOSITORIES: biostudies-literature
Van Rhijn Ildiko I Young David C DC Im Jin Seon JS Levery Steven B SB Illarionov Petr A PA Besra Gurdyal S GS Porcelli Steven A SA Gumperz Jenny J Cheng Tan-Yun TY Moody D Branch DB
Proceedings of the National Academy of Sciences of the United States of America 20040901 37
In addition to NK T cells expressing invariant Valpha14 or Valpha24 T cell receptors (TCRs), the CD1d-restricted T cell repertoire is comprised of T cells with diverse TCRs that mediate inflammation during autoimmune and infectious disease. Here we describe the isolation of human Valpha24(-) T cells that are activated by antigen and CD1d. Mass spectrometric and NMR studies revealed that the stimulatory compounds were neither peptidic nor lipidic but instead were composed of sulfur and aromatic h ...[more]