Ontology highlight
ABSTRACT:
SUBMITTER: Zimmer MI
PROVIDER: S-EPMC2644137 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Zimmer Michael I MI Nguyen Hanh P HP Wang Bin B Xu Honglin H Colmone Angela A Felio Kyrie K Choi Hak-Jong HJ Zhou Ping P Alegre Maria-Luisa ML Wang Chyung-Ru CR
Proceedings of the National Academy of Sciences of the United States of America 20090128 6
CD1 proteins constitute a distinct lineage of antigen-presenting molecules specialized for the presentation of lipid antigens to T cells. In contrast to the extensive sequence polymorphism characteristic of classical MHC molecules, CD1 proteins exhibit limited sequence diversity. Here, we describe the identification and characterization of CD1d alleles in wild-derived mouse strains. We demonstrate that polymorphisms in CD1d affect the presentation of endogenous and exogenous ligands to CD1d-rest ...[more]