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Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells.


ABSTRACT: CD1 proteins constitute a distinct lineage of antigen-presenting molecules specialized for the presentation of lipid antigens to T cells. In contrast to the extensive sequence polymorphism characteristic of classical MHC molecules, CD1 proteins exhibit limited sequence diversity. Here, we describe the identification and characterization of CD1d alleles in wild-derived mouse strains. We demonstrate that polymorphisms in CD1d affect the presentation of endogenous and exogenous ligands to CD1d-restricted T cells, including type I (Valpha14i) and type II (non-Valpha14i) natural killer T (NKT) cells. Using congenic mice, we found CD1d polymorphisms affect the thymic selection of type I NKT cells and induce allogeneic T cell responses. Collectively, results from these studies demonstrate a role for polymorphisms in influencing the development and function of CD1d-restricted T cells.

SUBMITTER: Zimmer MI 

PROVIDER: S-EPMC2644137 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature

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Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells.

Zimmer Michael I MI   Nguyen Hanh P HP   Wang Bin B   Xu Honglin H   Colmone Angela A   Felio Kyrie K   Choi Hak-Jong HJ   Zhou Ping P   Alegre Maria-Luisa ML   Wang Chyung-Ru CR  

Proceedings of the National Academy of Sciences of the United States of America 20090128 6


CD1 proteins constitute a distinct lineage of antigen-presenting molecules specialized for the presentation of lipid antigens to T cells. In contrast to the extensive sequence polymorphism characteristic of classical MHC molecules, CD1 proteins exhibit limited sequence diversity. Here, we describe the identification and characterization of CD1d alleles in wild-derived mouse strains. We demonstrate that polymorphisms in CD1d affect the presentation of endogenous and exogenous ligands to CD1d-rest  ...[more]

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