Dataset Information

Association between Dietary Intakes of Nitrate and Nitrite and the Risk of Hypertension and Chronic Kidney Disease: Tehran Lipid and Glucose Study.

ABSTRACT:

Background and aim

The association of habitual intakes of dietary nitrate (NO?^-) and nitrite (NO?^-) with blood pressure and renal function is not clear. Here, we investigated a potential effect of dietary NO?^- and NO?^- on the occurrence of hypertension (HTN) and chronic kidney disease (CKD).

Methods

A total of 2799 Iranian adults aged ?20 years, participating in the Tehran Lipid and Glucose Study (TLGS), were included and followed for a median of 5.8 years. Dietary intakes of NO?^- and NO?^- were estimated using a semi-quantitative food frequency questionnaire. Demographics, anthropometrics, blood pressure and biochemical variables were evaluated at baseline and during follow-up examinations. To identify the odds ratio (OR) and 95% confidence interval (CI) of HTN and CKD across tertile categories of residual energy-adjusted NO?^- and NO?^- intakes, multivariate logistic regression models were used.

Results

Dietary intake of NO?^- had no significant association with the risk of HTN or CKD. Compared to the lowest tertile category (median intake < 6.04 mg/day), the highest intake (median intake ? 12.7 mg/day) of dietary NO?^- was accompanied with a significant reduced risk of HTN, in the fully adjusted model (OR = 0.58, 95% CI = 0.33-0.98; p for trend = 0.054). The highest compared to the lowest tertile of dietary NO?^- was also accompanied with a reduced risk of CKD (OR = 0.50, 95% CI = 0.24-0.89, p for trend = 0.07).

Conclusion

Our findings indicated that higher intakes of NO?^- might be an independent dietary protective factor against the development of HTN and CKD, which are major risk factors for adverse cardiovascular events.

SUBMITTER: Bahadoran Z

PROVIDER: S-EPMC5188466 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Publications

Association between Dietary Intakes of Nitrate and Nitrite and the Risk of Hypertension and Chronic Kidney Disease: Tehran Lipid and Glucose Study.

Bahadoran Zahra Z Mirmiran Parvin P Ghasemi Asghar A Carlström Mattias M Azizi Fereidoun F Hadaegh Farzad F Hadaegh Farzad F

Nutrients 20161221 12

<h4>Background and aim</h4>The association of habitual intakes of dietary nitrate (NO₃<sup>-</sup>) and nitrite (NO₂<sup>-</sup>) with blood pressure and renal function is not clear. Here, we investigated a potential effect of dietary NO₃<sup>-</sup> and NO₂<sup>-</sup> on the occurrence of hypertension (HTN) and chronic kidney disease (CKD).<h4>Methods</h4>A total of 2799 Iranian adults aged ≥20 years, participating in the Tehran Lipid and Glucose Study (TLGS), were included and followed for a ...[more]

PMID: 28009811

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Dataset Information

Association between Dietary Intakes of Nitrate and Nitrite and the Risk of Hypertension and Chronic Kidney Disease: Tehran Lipid and Glucose Study.

Background and aim

Methods

Results

Conclusion

Publications

Association between Dietary Intakes of Nitrate and Nitrite and the Risk of Hypertension and Chronic Kidney Disease: Tehran Lipid and Glucose Study.

Similar Datasets

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