Ontology highlight
ABSTRACT:
SUBMITTER: Adams WC
PROVIDER: S-EPMC5189677 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Adams William C WC Chen Yen-Hua YH Kratchmarov Radomir R Yen Bonnie B Nish Simone A SA Lin Wen-Hsuan W WW Rothman Nyanza J NJ Luchsinger Larry L LL Klein Ulf U Busslinger Meinrad M Rathmell Jeffrey C JC Snoeck Hans-Willem HW Reiner Steven L SL
Cell reports 20161201 12
Regeneration requires related cells to diverge in fate. We show that activated lymphocytes yield sibling cells with unequal elimination of aged mitochondria. Disparate mitochondrial clearance impacts cell fate and reflects larger constellations of opposing metabolic states. Differentiation driven by an anabolic constellation of PI3K/mTOR activation, aerobic glycolysis, inhibited autophagy, mitochondrial stasis, and ROS production is balanced with self-renewal maintained by a catabolic constellat ...[more]