Dataset Information

High-density lipoprotein cholesterol as a predictor of poor survival in patients with nasopharyngeal carcinoma.

ABSTRACT:

Purpose

We aimed to assess the prognostic value of pretreatment high density lipoprotein cholesterol (HDL-C) levels in patients with nasopharyngeal carcinoma (NPC) and investigate the possible biological effects of these lipoproteins on NPC cells in vitro.

Experimental design

We examined the prognostic value of pretreatment HDL-C levels in 2443 patients with non-metastatic NPC from three independent institutions. The Cox proportional hazard model and log-rank test were used to analyze the correlation between HDL-C levels and overall survival (OS). Cell growth, colony formation, and apoptotic assays were used to determine the biological functions of HDL on NPC cells in vitro. All of the statistical tests were two-sided.

Results

OS was decreased in patients with high pretreatment HDL-C levels compared with those with low HDL-C levels (P < 0.05). Similarly, a decreased OS was noted in advanced stage (stage III-IV), NPC patients with high pretreatment HDL-C levels (P < 0.01). Multivariate analyses indicated that HDL-C was an independent prognostic factor associated with shorter OS in training cohorts. These findings were confirmed in both independent validation cohorts (P < 0.01). In vitro experiments demonstrated that HDL could increase cell proliferation, invasion, and colony formation, which were largely dependent on the expression of its receptor SR-B1. Finally, HDL could enhance chemoresistance by protecting cancer cells from apoptosis.

Conclusions

Pretreatment HDL-C is a poor prognostic factor for patients with NPC. This effect may be associated with the ability of HDL to enhance proliferation, colony formation, migration, and chemoresistance in NPC cells.

SUBMITTER: Liu YY

PROVIDER: S-EPMC5190001 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Publications

High-density lipoprotein cholesterol as a predictor of poor survival in patients with nasopharyngeal carcinoma.

Liu Yan-Yan YY Lin Shao-Jun SJ Chen Yuan-Yuan YY Liu Li-Na LN Bao Liu-Bin LB Tang Lin-Quan LQ Ou Jing-Song JS Liu Zhi-Gang ZG Chen Xiao-Zhong XZ Xu Yan Y Ma Jun J Chan Anthony T AT Chen Ming M Xia Yun-Fei YF Liu Wan-Li WL Zeng Yi-Xin YX Mai Hai-Qiang HQ Zeng Mu-Sheng MS Pan Jian-Ji JJ Zhang Xing X

Oncotarget 20160701 28

<h4>Purpose</h4>We aimed to assess the prognostic value of pretreatment high density lipoprotein cholesterol (HDL-C) levels in patients with nasopharyngeal carcinoma (NPC) and investigate the possible biological effects of these lipoproteins on NPC cells in vitro.<h4>Experimental design</h4>We examined the prognostic value of pretreatment HDL-C levels in 2443 patients with non-metastatic NPC from three independent institutions. The Cox proportional hazard model and log-rank test were used to ana ...[more]

PMID: 27304186

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Dataset Information

High-density lipoprotein cholesterol as a predictor of poor survival in patients with nasopharyngeal carcinoma.

Purpose

Experimental design

Results

Conclusions

Publications

High-density lipoprotein cholesterol as a predictor of poor survival in patients with nasopharyngeal carcinoma.

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