Ontology highlight
ABSTRACT:
SUBMITTER: Jansen MP
PROVIDER: S-EPMC5190033 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Jansen Maurice Phm MP Martens John Wm JW Helmijr Jean Ca JC Beaufort Corine M CM van Marion Ronald R Krol Niels Mg NM Monkhorst Kim K Trapman-Jansen Anita Mac AM Meijer-van Gelder Marion E ME Weerts Marjolein Ja MJ Ramirez-Ardila Diana E DE Dubbink Hendrikus Jan HJ Foekens John A JA Sleijfer Stefan S Berns Els Mjj EM
Oncotarget 20160701 28
The aim was to identify mutations in serum cell-free DNA (cfDNA) associated with disease progression on tamoxifen treatment in metastatic breast cancer (MBC). Sera available at start of therapy, during therapy and at disease progression were selected from 10 estrogen receptor (ER)-positive breast cancer patients. DNA from primary tumor and normal tissue and cfDNA from minute amounts of sera were analyzed by targeted next generation sequencing (NGS) of 45 genes (1,242 exons). At disease progressi ...[more]