Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer.
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ABSTRACT:
SUBMITTER: Han S
PROVIDER: S-EPMC5190106 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer.
Han Shiwei S Ma Xuemei X Zhao Yanxia Y Zhao Hongying H Batista Ana A Zhou Sheng S Zhou Xiaona X Yang Yao Y Wang Tingting T Bi Jingtao J Xia Zheng Z Bai Zhigang Z Garkavtsev Igor I Zhang Zhongtao Z
Oncotarget 20160701 28
Gastric cancer is a prevalent tumor that is usually detected at an advanced metastatic stage. Currently, standard therapies are mostly ineffective. Here, we report that Glypican-3 (GPC3) is absent in invasive tumors and metastatic lymph nodes, in particular in aggressive and highly disseminated signet ring cell carcinomas. We demonstrate that loss of GPC3 correlates with poor overall survival in patients. Moreover, we show that absence of GPC3 causes up-regulation of MAPK/FoxM1 signaling and tha ...[more]
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