MIM, a potential metastasis suppressor gene in bladder cancer.
Ontology highlight
ABSTRACT:
SUBMITTER: Lee YG
PROVIDER: S-EPMC1531703 | biostudies-other | 2002 Jul-Aug
REPOSITORIES: biostudies-other
Publications
MIM, a potential metastasis suppressor gene in bladder cancer.
Lee Young-Goo YG Macoska Jill A JA Korenchuk Susan S Pienta Kenneth J KJ
Neoplasia (New York, N.Y.) 20020701 4
Using a modified version of the mRNA differential display technique, five human bladder cancer cell lines from low grade to metastatic were analyzed to identify differences in gene expression. A 316-bp cDNA (C11-300) was isolated that was not expressed in the metastatic cell line TccSuP. Sequence analysis revealed that this gene was identical to KIAA 0429, has a 5.3-kb transcript that mapped to 8q24.1. The protein is predicted to be 356 amino acids in size and has an actin-binding WH2 domain. No ...[more]
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