Ontology highlight
ABSTRACT:
SUBMITTER: Detienne G
PROVIDER: S-EPMC5190145 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Detienne Giel G Van de Walle Pieter P De Haes Wouter W Schoofs Liliane L Temmerman Liesbet L
Worm 20160831 4
In <i>C. elegans</i> research, transcriptional activation of glutathione S-transferase 4 (<i>gst-4</i>) is often used as a read-out for SKN-1 activity. While many heed an assumed non-exclusivity of the GFP reporter signal driven by the <i>gst-4</i> promoter to SKN-1, this is also often ignored. We here show that <i>gst-4</i> can also be transcriptionally activated by EOR-1, a transcription factor mediating effects of the epidermal growth factor (EGF) pathway. Along with enhancing exogenous oxida ...[more]