Ontology highlight
ABSTRACT:
SUBMITTER: Muthusamy N
PROVIDER: S-EPMC5191939 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Muthusamy Nagendran N Zhang Xuying X Johnson Caroline A CA Yadav Prem N PN Ghashghaei H Troy HT
Nature neuroscience 20161205 1
Postnatal and adult neurogenesis are region- and modality-specific, but the significance of developmentally distinct neuronal populations remains unclear. We demonstrate that chemogenetic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses to an aversive odor. In contrast, novel appetitive odor learning is sensitive to inactivation of adult-born neurons, revealing that developmentally defined sets of neurons may differentially participate in hedonic ...[more]