Dataset Information

Depressive symptoms in women's midlife in relation to their body weight before, during and after childbearing years.

ABSTRACT:

Objective

This study aimed to examine how weight and weight changes related to pregnancy were associated with depressive symptoms 11-16 years after childbirth.

Method

We followed 16,998 first-time mothers from the Danish National Birth Cohort up till 16 years after birth and estimated associations between depressive symptoms and pre-pregnancy body mass index (BMI) (kg m^-2), weight changes in different time periods, and BMI-adjusted waist circumference 7 years after birth (WC_BMI, cm). Depressive symptoms were estimated by the Center for Epidemiologic Studies Depression 10-item scale. Multiple logistic regression analyses were used to estimate odds ratios (OR) and 95% confidence intervals.

Results

Compared with normal-weight, we found that underweight, overweight and obesity were associated with greater odds of depressive symptoms (1.29, 1.24 and 1.73, respectively). Compared with weight change ±1 BMI unit during the total follow-up period, greater odds for depressive symptoms were observed with weight loss (OR 1.14, 0.96-1.36) or gain of 2-2.99 kg m^-2 (OR 1.11, 0.92-1.33) or gain of ≥3 kg m^-2 (OR 1.68, 1.46-1.94). WC_BMI > 2.2 cm was associated with greater odds of depressive symptoms (OR 1.16, 0.99-1.36) than waist circumference as predicted by BMI.

Conclusion

Low and high pre-pregnancy BMI, weight changes and WC_BMI larger than predicted were associated with more depressive symptoms in midlife.

SUBMITTER: Bliddal M

PROVIDER: S-EPMC5192541 | biostudies-literature |

REPOSITORIES: biostudies-literature

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