Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC5192974 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Liu Zheng Z Gutierrez-Vargas Cristina C Wei Jia J Grassucci Robert A RA Sun Ming M Espina Noel N Madison-Antenucci Susan S Tong Liang L Frank Joachim J
Protein science : a publication of the Protein Society 20161026 1
With the advance of new instruments and algorithms, and the accumulation of experience over decades, single-particle cryo-EM has become a pivotal part of structural biology. Recently, we determined the structure of a eukaryotic ribosome at 2.5 Å for the large subunit. The ribosome was derived from Trypanosoma cruzi, the protozoan pathogen of Chagas disease. The high-resolution density map allowed us to discern a large number of unprecedented details including rRNA modifications, water molecules, ...[more]