Ontology highlight
ABSTRACT:
SUBMITTER: DeLaughter DM
PROVIDER: S-EPMC5198784 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
DeLaughter Daniel M DM Bick Alexander G AG Wakimoto Hiroko H McKean David D Gorham Joshua M JM Kathiriya Irfan S IS Hinson John T JT Homsy Jason J Gray Jesse J Pu William W Bruneau Benoit G BG Seidman J G JG Seidman Christine E CE
Developmental cell 20161110 4
Activation of complex molecular programs in specific cell lineages governs mammalian heart development, from a primordial linear tube to a four-chamber organ. To characterize lineage-specific, spatiotemporal developmental programs, we performed single-cell RNA sequencing of >1,200 murine cells isolated at seven time points spanning embryonic day 9.5 (primordial heart tube) to postnatal day 21 (mature heart). Using unbiased transcriptional data, we classified cardiomyocytes, endothelial cells, an ...[more]