The effect of the top 20 Alzheimer disease risk genes on gray-matter density and FDG PET brain metabolism.
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ABSTRACT:
SUBMITTER: Stage E
PROVIDER: S-EPMC5198883 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
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The effect of the top 20 Alzheimer disease risk genes on gray-matter density and FDG PET brain metabolism.
Stage Eddie E Duran Tugce T Risacher Shannon L SL Goukasian Naira N Do Triet M TM West John D JD Wilhalme Holly H Nho Kwangsik K Phillips Meredith M Elashoff David D Saykin Andrew J AJ Apostolova Liana G LG
Alzheimer's & dementia (Amsterdam, Netherlands) 20161219
<h4>Introduction</h4>We analyzed the effects of the top 20 Alzheimer disease (AD) risk genes on gray-matter density (GMD) and metabolism.<h4>Methods</h4>We ran stepwise linear regression analysis using posterior cingulate hypometabolism and medial temporal GMD as outcomes and all risk variants as predictors while controlling for age, gender, and <i>APOE</i> ε4 genotype. We explored the results in 3D using Statistical Parametric Mapping 8.<h4>Results</h4>Significant predictors of brain GMD were < ...[more]
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