Ontology highlight
ABSTRACT:
SUBMITTER: Apostolova LG
PROVIDER: S-EPMC5885860 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Apostolova Liana G LG Risacher Shannon L SL Duran Tugce T Stage Eddie C EC Goukasian Naira N West John D JD Do Triet M TM Grotts Jonathan J Wilhalme Holly H Nho Kwangsik K Phillips Meredith M Elashoff David D Saykin Andrew J AJ
JAMA neurology 20180301 3
<h4>Importance</h4>Late-onset Alzheimer disease (AD) is highly heritable. Genome-wide association studies have identified more than 20 AD risk genes. The precise mechanism through which many of these genes are associated with AD remains unknown.<h4>Objective</h4>To investigate the association of the top 20 AD risk variants with brain amyloidosis.<h4>Design, setting, and participants</h4>This study analyzed the genetic and florbetapir F 18 data from 322 cognitively normal control individuals, 496 ...[more]