Ontology highlight
ABSTRACT:
SUBMITTER: Lin W
PROVIDER: S-EPMC5199165 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Lin Wenchu W Francis Joshua M JM Li Hong H Gao Xiaoping X Pedamallu Chandra Sekhar CS Ernst Patricia P Meyerson Matthew M
Cancer biology & therapy 20161101 12
The reported incidence of pancreatic neuroendocrine tumors (PanNETs) has increased, due in large part to improvements in detection and awareness. However, therapeutic options are limited and a critical need exists for understanding a more thorough characterization of the molecular pathology underlying this disease. The Men1 knockout mouse model recapitulates the early stage of human PanNET development and can serve as a foundation for the development of advanced mouse models that are necessary f ...[more]