Ontology highlight
ABSTRACT:
SUBMITTER: Ehrmann I
PROVIDER: S-EPMC5199341 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Ehrmann Ingrid I Gazzara Matthew R MR Pagliarini Vittoria V Dalgliesh Caroline C Kheirollahi-Chadegani Mahsa M Xu Yaobo Y Cesari Eleonora E Danilenko Marina M Maclennan Marie M Lowdon Kate K Vogel Tanja T Keskivali-Bond Piia P Wells Sara S Cater Heather H Fort Philippe P Santibanez-Koref Mauro M Middei Silvia S Sette Claudio C Clowry Gavin J GJ Barash Yoseph Y Cunningham Mark O MO Elliott David J DJ
Cell reports 20161201 12
The brain is made up of trillions of synaptic connections that together form neural networks needed for normal brain function and behavior. SLM2 is a member of a conserved family of RNA binding proteins, including Sam68 and SLM1, that control splicing of Neurexin1-3 pre-mRNAs. Whether SLM2 affects neural network activity is unknown. Here, we find that SLM2 levels are maintained by a homeostatic feedback control pathway that predates the divergence of SLM2 and Sam68. SLM2 also controls the splici ...[more]